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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Summary of Domestic and Foreign Pre-tax Loss

Domestic and foreign pre-tax loss is as follows (in thousands):

		Years Ended December 31,
		2018				2017				2016
Domestic			(78,112	)		$	(45,249	)		$	(18,419	)
Foreign			(165,824	)			(243,035	)			(251,633	)
			(243,936	)		$	(288,284	)		$	(270,052	)

Components of Deferred Tax Assets

The components of the deferred tax assets are as follows (in thousands):

		December 31,
		2018				2017
NOL carryforwards		$	170,476			$	163,059
R&D credit carryforwards			32,984				27,862
Capitalized R&D			7,421				5,606
Stock-based compensation			45,492				30,986
Other			14,750				10,110
			271,123				237,623
Valuation allowance			(271,123	)			(237,623	)
		$	—			$	—

Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss

A reconciliation of income taxes to the amount computed by applying the statutory federal income tax rate to the pretax loss is summarized as follows (in thousands):

		Years Ended December 31,
		2018				2017				2016
Amounts computed at statutory federal rate		$	(51,226	)		$	(98,016	)		$	(91,818	)
Stock-based compensation and other permanent differences			3,432				1,341				3,065
R&D credits			(7,941	)			(5,573	)			(3,390	)
Change in valuation allowance			34,333				(28,230	)			27,583
State taxes			(1,017	)			(26	)			272
Contingencies			2,938				360				361
Foreign rate differential			20,896				61,480				64,065
Tax Cuts and Jobs Act			—				68,889				—
Other			(159	)			894				1,203
Income tax expense		$	1,256			$	1,119			$	1,341

Unrecognized Tax Benefits

The following table provides a reconciliation of changes in unrecognized tax benefits (in thousands):

		Years Ended December 31,
		2018				2017				2016
Balance at beginning of period		$	1,933			$	2,664			$	2,301
Additions related to current period tax positions			3,104				361				363
Provisional impact of Tax Cuts and Jobs Act			—				(1,092	)			—
Balance at end of period		$	5,037			$	1,933			$	2,664

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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