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Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018		Dec. 31, 2017		Dec. 31, 2016
Revenues
Total revenues	$ 223,807		$ 124,901		$ 17,331
Operating expenses
License fees and royalties	5,953		3,983		1,331
Research and development	187,163		149,189		99,284
Selling, general and administrative	265,758		255,062		186,456
Total operating expenses	471,251		417,311		290,146
Loss from operations	(247,444)		(292,410)		(272,815)
Interest income, net	5,348		4,126		2,763
Other expense	(1,840)
Loss before income taxes	(243,936)		(288,284)		(270,052)
Income tax expense	1,256		1,119		1,341
Net loss	$ (245,192)		$ (289,403)		$ (271,393)
Net loss per common share, basic and diluted	$ (1.94)	[1]	$ (2.36)	[1]	$ (2.34)
Weighted average common shares outstanding, basic and diluted	126,583		122,600		115,858
Product [Member]
Revenues
Product sales, net	$ 223,807		$ 124,901		$ 17,327
Operating expenses
Cost of product sales	$ 12,377		$ 9,077		3,075
Product and Service, Other [Member]
Revenues
Product sales, net					$ 4
[1] Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.

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