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Summary of Company's Stock Option Activity (Detail)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2018
USD ($)
$ / shares
shares
Number of Shares  
Options Outstanding, Beginning Balance | shares 17,943,436
Granted | shares 5,273,665
Exercised | shares (599,529)
Cancelled/forfeited | shares (2,748,791)
Options Outstanding, Ending Balance | shares 19,868,781
Vested and expected to vest | shares 19,868,781
Exercisable | shares 9,342,575
Weighted Average Exercise Prices  
Weighted Average Exercise Prices, Beginning Balance | $ / shares $ 30.42
Weighted Average Exercise Prices, granted | $ / shares 19.24
Weighted Average Exercise Prices, exercised | $ / shares 7.39
Weighted Average Exercise Prices, Cancelled/forfeited | $ / shares 31.19
Weighted Average Exercise Prices, Ending Balance | $ / shares 28.04
Weighted Average Exercise Prices, Vested and expected to vest | $ / shares 28.04
Weighted Average Exercise Prices, Exercisable | $ / shares $ 29.50
Weighted average remaining contractual term, Outstanding 7 years 7 months 6 days
Weighted average remaining contractual term, Vested and expected to vest 7 years 7 months 6 days
Weighted average remaining contractual term, Exercisable 6 years 4 months 24 days
Aggregate Intrinsic Value, Outstanding | $ $ 4,592
Aggregate Intrinsic Value, Vested and expected to vest | $ 4,592
Aggregate Intrinsic Value, Exercisable | $ $ 4,139