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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Income Tax Disclosure [Abstract]
NOL carryforwards	$ 170,476	$ 163,059
R&D credit carryforwards	32,984	27,862
Capitalized R&D	7,421	5,606
Stock-based compensation	45,492	30,986
Other	14,750	10,110
Deferred Tax Assets, Gross	271,123	237,623
Valuation allowance	$ (271,123)	(237,623)
Deferred Tax Assets, Net		$ 0

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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