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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (51,226)	$ (98,016)	$ (91,818)
Stock-based compensation and other permanent differences	3,432	1,341	3,065
R&D credits	(7,941)	(5,573)	(3,390)
Change in valuation allowance	34,333	(28,230)	27,583
State taxes	(1,017)	(26)	272
Contingencies	2,938	360	361
Foreign rate differential	20,896	61,480	64,065
Tax Cuts and Jobs Act		68,889
Other	(159)	894	1,203
Income tax expense	$ 1,256	$ 1,119	$ 1,341

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