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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 3 Months Ended 12 Months Ended
Aug. 31, 2018
USD ($)
May 31, 2018
USD ($)
shares
Dec. 31, 2018
USD ($)
ft²
Dec. 31, 2018
USD ($)
ft²
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Other Commitments [Line Items]              
Operating lease, expiration year       2031-02      
Rent expense       $ 4,500,000 $ 3,800,000 $ 2,800,000  
Restricted cash     $ 4,826,000 4,826,000 $ 2,475,000 2,375,000 $ 375,000
Loss on strategic investment       1,840,000      
Other assets              
Other Commitments [Line Items]              
Aggregate carrying amount of strategic equity investment     $ 1,300,000 1,300,000      
Other expense              
Other Commitments [Line Items]              
Loss on strategic investment       1,800,000      
Exclusivity Deed | Neuren              
Other Commitments [Line Items]              
Aggregate carrying amount of strategic equity investment   $ 3,100,000          
Shares subscribed | shares   1,330,000          
Exclusivity Deed | Neuren | Sales, general and administrative              
Other Commitments [Line Items]              
Payments for exclusive right   $ 900,000          
North America | License Agreements | Neuren              
Other Commitments [Line Items]              
Upfront payment $ 10,000,000            
North America | License Agreements | Neuren | Research and development              
Other Commitments [Line Items]              
Upfront payment       10,000,000      
Corporate Office Space Lease Agreement              
Other Commitments [Line Items]              
Rent expense       $ 0      
Operating leases arrangement term     10 years 9 months 10 years 9 months      
Operating leases commencement year     2020-05        
Operating leases renewal term       two additional five year periods      
Corporate Office Space Lease Agreement | California              
Other Commitments [Line Items]              
Office space leases in square feet | ft²     67,020 67,020      
Maximum              
Other Commitments [Line Items]              
Percentage of royalty payments obligation on net product sales       2.00%      
Maximum | North America | License Agreements | Neuren              
Other Commitments [Line Items]              
Milestone payments payable $ 455,000,000            
Letter of Credit              
Other Commitments [Line Items]              
Restricted cash             $ 400,000
Letter of Credit | Corporate Credit Card Program              
Other Commitments [Line Items]              
Restricted cash           $ 2,000,000  
Letter of Credit | Corporate Office Space Lease Agreement              
Other Commitments [Line Items]              
Restricted cash     $ 2,200,000 $ 2,200,000      
Vehicles [Member]              
Other Commitments [Line Items]              
Operating leases arrangement term             36 months
Vehicles [Member] | Minimum              
Other Commitments [Line Items]              
Operating leases arrangement term             12 months
Vehicles [Member] | Maximum              
Other Commitments [Line Items]              
Operating leases arrangement term             50 months