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Selected Quarterly Financial Data (Unaudited) - Selected Quarterly Financial Data (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]                      
Revenues $ 59,571 $ 58,305 $ 57,063 $ 48,868 $ 43,562 $ 35,578 $ 30,475 $ 15,286 $ 223,807 $ 124,901  
Gross profit [1] 56,748 54,466 53,501 46,715 41,107 33,443 28,251 13,023 211,430 115,824  
Net loss $ (65,492) $ (62,138) $ (63,266) $ (54,296) $ (68,871) $ (65,248) $ (67,441) $ (87,843) $ (245,192) $ (289,403) $ (271,393)
Basic and diluted net loss per share $ (0.50) [2] $ (0.50) [2] $ (0.51) [2] $ (0.44) [2] $ (0.55) [2] $ (0.53) [2] $ (0.55) [2] $ (0.72) [2] $ (1.94) [2] $ (2.36) [2] $ (2.34)
[1] Determined by subtracting cost of product sales from product sales, net.
[2] Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.