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Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Cash flows from operating activities
Net loss	$ (245,192)	$ (289,403)	$ (271,393)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	81,564	75,532	55,265
Amortization of premiums and accretion of discounts on investment securities	(578)	(291)	89
Amortization of intangible assets	1,476	1,477	985
Loss on strategic investment	1,840
Depreciation	1,529	1,236	843
Income tax benefit from exercise of stock options			(596)
Loss on disposal of assets	88	4	5
Changes in operating assets and liabilities:
Accounts receivable, net	(8,747)	(11,440)	(5,903)
Interest and other receivables	(612)	150	401
Inventory	1,926	(1,012)	(3,305)
Prepaid expenses and other current assets	(12,270)	(911)	(4,731)
Other assets	(236)	431	(456)
Accounts payable	(5,619)	4,874	2,240
Accrued liabilities	15,994	4,206	15,579
Deferred revenue		(2,644)	2,644
Long-term liabilities	1,367	34	(75)
Net cash used in operating activities	(167,470)	(217,757)	(208,408)
Cash flows from investing activities
Purchases of investment securities	(327,914)	(478,818)	(683,355)
Maturities of investment securities	261,678	572,103	430,937
Purchases of strategic investments	(3,149)
Intangible assets			(8,000)
Proceeds from sale of property and equipment	44
Purchases of property and equipment	(2,148)	(812)	(1,506)
Net cash (used in) provided by investing activities	(71,489)	92,473	(261,924)
Cash flows from financing activities
Proceeds from issuance of common stock, net of issuance costs	306,647	31,188	518,896
Proceeds from settlement agreement			14,320
Income tax benefit from exercise of stock options			596
Net cash provided by financing activities	306,647	31,188	533,812
Effect of exchange rate changes on cash	3	(6)	2
Net increase (decrease) in cash, cash equivalents and restricted cash	67,691	(94,102)	63,482
Cash, cash equivalents and restricted cash
Beginning of period	71,893	165,995	102,513
End of period	139,584	71,893	165,995
Supplemental disclosure of cash flow information:
Cash paid for income taxes	1,261	1,367	365
Supplemental disclosure of noncash information:
Property and equipment purchases in accounts payable and accrued liabilities	160	9	220
Stock-based compensation capitalized in inventory	$ (748)	$ (61)	$ 870

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The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method.

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The amount of fixed assets that an Entity acquires in a noncash (or part noncash) acquisition. Noncash is defined as information about all investing and financing activities of an enterprise during a period that affect recognized assets or liabilities but that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period.

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The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity.

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The cash outflow to acquire equity securities classified as available-for-sale securities, because they are not classified as trading securities.

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The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill.

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The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.

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The cash inflow associated with the amount received by a corporation from a shareholder during the period.

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The cash inflow from the additional capital contribution to the entity.

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Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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