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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance at Dec. 31, 2015 $ 199,762 $ 10 $ 862,327 $ (662,586) $ 11
Beginning balance (in shares) at Dec. 31, 2015   101,938,702      
Issuance of common stock in public offering, net of issuance costs 497,765 $ 2 497,763    
Issuance of common stock in public offering, net of issuance costs (in shares)   17,314,523      
Issuance of common stock from exercise of stock options 18,000   18,000    
Issuance of common stock from exercise of stock options (in shares)   1,977,661      
Issuance of common stock pursuant to employee stock purchase plan 3,131   3,131    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   136,283      
Income tax benefit from exercise of stock options 596   596    
Proceeds from settlement agreement 14,320   14,320    
Net loss (271,393)     (271,393)  
Stock-based compensation 56,135   56,135    
Other comprehensive income (loss) 95       95
Ending balance at Dec. 31, 2016 518,411 $ 12 1,452,272 (933,979) 106
Ending balance (in shares) at Dec. 31, 2016   121,367,169      
Issuance of common stock from exercise of stock options 26,665   26,665    
Issuance of common stock from exercise of stock options (in shares)   1,442,411      
Issuance of common stock pursuant to employee stock purchase plan 4,522   4,522    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   192,402      
Issuance of common stock from exercise of warrants on a net issuance basis (in shares)   1,408,570      
Net loss (289,403)     (289,403)  
Cumulative effect adjustment from adoption of ASU 2016-09 (289)     (289)  
Stock-based compensation 75,884   75,884    
Other comprehensive income (loss) (505)       (505)
Ending balance at Dec. 31, 2017 335,285 $ 12 1,559,343 (1,223,671) (399)
Ending balance (in shares) at Dec. 31, 2017   124,410,552      
Issuance of common stock in public offering, net of issuance costs 298,537 $ 2 298,535    
Issuance of common stock in public offering, net of issuance costs (in shares)   18,602,941      
Issuance of common stock from exercise of stock options $ 4,428   4,428    
Issuance of common stock from exercise of stock options (in shares) 599,529 599,529      
Issuance of common stock pursuant to employee stock purchase plan $ 3,682   3,682    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   233,720      
Issuance of common stock from exercise of warrants on a net issuance basis (in shares)   6,855      
Net loss (245,192)     (245,192)  
Stock-based compensation 82,312   82,312    
Other comprehensive income (loss) 27       27
Ending balance at Dec. 31, 2018 $ 479,079 $ 14 $ 1,948,300 $ (1,468,863) $ (372)
Ending balance (in shares) at Dec. 31, 2018   143,853,597