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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Cash flows from operating activities
Net loss	$ (85,304)	$ (54,296)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	19,883	20,442
Amortization of premiums and accretion of discounts on investment securities	(1,006)	(175)
Amortization of intangible assets	370	369
Loss on strategic investment	229
Depreciation	415	392
Loss on disposal of assets		9
Changes in operating assets and liabilities:
Accounts receivable, net	(3,868)	(5,102)
Interest and other receivables	(2,113)	184
Inventory	(557)	(177)
Prepaid expenses	(3,015)	(4,563)
Operating lease right-of-use assets	833
Other assets	105	31
Accounts payable	108	(5,790)
Accrued liabilities	11,035	2,849
Operating lease liabilities	(938)
Long-term liabilities	(352)	591
Net cash used in operating activities	(64,175)	(45,236)
Cash flows from investing activities
Purchases of investment securities	(73,945)	(26,345)
Maturities of investment securities	97,525	116,411
Purchases of property and equipment	(822)	(448)
Net cash provided by investing activities	22,758	89,618
Cash flows from financing activities
Proceeds from issuance of common stock, net of issuance costs	4,176	2,880
Net cash provided by financing activities	4,176	2,880
Effect of exchange rate changes on cash	1	(2)
Net (decrease) increase in cash, cash equivalents and restricted cash	(37,240)	47,260
Cash, cash equivalents and restricted cash
Beginning of period	139,584	71,893
End of period	102,344	119,153
Supplemental disclosure of noncash information:
Property and equipment purchases in accounts payable and accrued liabilities	21
Stock-based compensation capitalized in inventory	57	$ (158)
Right-of-use assets obtained in exchange for lease obligations	$ 11,751

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