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Commitments and Contingencies - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended
	Aug. 31, 2018	May 31, 2018	Mar. 31, 2019	Sep. 30, 2018	Dec. 31, 2018	Mar. 31, 2018	Dec. 31, 2017
Other Commitments [Line Items]
Loss on strategic investment			$ 229,000
Restricted cash			4,787,000		$ 4,826,000	$ 2,825,000	$ 2,475,000
Letter of Credit | Corporate Credit Card Program
Other Commitments [Line Items]
Restricted cash			2,000,000
Letter of Credit | Fleet Program
Other Commitments [Line Items]
Restricted cash			400,000
Other assets
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment			1,100,000		$ 1,300,000
Other expense
Other Commitments [Line Items]
Loss on strategic investment			$ 200,000
Exclusivity Deed | Neuren
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment		$ 3,100,000
Shares subscribed		1,330,000
Exclusivity Deed | Neuren | Selling, general and administrative
Other Commitments [Line Items]
Payments for exclusive right		$ 900,000
License Agreements | Neuren | North America
Other Commitments [Line Items]
Upfront license fee	$ 10,000,000
License Agreements | Neuren | Research and development | North America
Other Commitments [Line Items]
Upfront payment				$ 10,000,000
Maximum
Other Commitments [Line Items]
Percentage of royalty payments obligation on net product sales			2.00%
Maximum | License Agreements | Neuren | North America
Other Commitments [Line Items]
Additional milestone payments payable	$ 455,000,000

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