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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
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Total revenues	$ 62,959	$ 48,868
Operating expenses
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Cost of product sales	$ 2,950	$ 2,153
License fees and royalties	1,630	1,332
Research and development	52,923	39,276
Selling, general and administrative	93,090	60,926
Total operating expenses	150,593	103,687
Loss from operations	(87,634)	(54,819)
Interest income, net	2,934	1,170
Other expense	(229)
Loss before income taxes	(84,929)	(53,649)
Income tax expense	375	647
Net loss	$ (85,304)	$ (54,296)
Net loss per common share, basic and diluted	$ (0.59)	$ (0.44)
Weighted average common shares outstanding, basic and diluted	143,981	124,727

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