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Stockholders' Equity - Additional Information (Detail) | 1 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Nov. 30, 2018 USD ($) shares | Aug. 31, 2016 USD ($) shares | Jan. 31, 2016 USD ($) shares | Dec. 31, 2012 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) shares | Jun. 30, 2018 USD ($) | Dec. 31, 2018 USD ($)
Class of Stock [Line Items] |  |  |  |  |  |  |
Net proceeds from sale of common stock | $ 298,500,000 | $ 215,900,000 | $ 281,600,000 |  | $ 8,822,000 | $ 5,833,000 |
Share of common stock issued | shares | 18,602,941 | 6,969,696 | 10,344,827 | 19,000,000 |  |  |
Value of shares purchased by Baker Entities in public offerings |  |  |  |  | $ 14,000 |  | $ 14,000
Proceed from sale of stock and warrants |  |  |  | $ 80,500,000 |  |  |
Common stock sale price per share | $ / shares |  |  |  | $ 4.43 |  |  |
Expire on December 17, 2019 |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Warrants issued | shares |  |  |  | 500,000 |  |  |
Warrants issuance price per share | $ / shares |  |  |  | $ 4.42 |  |  |
Warrant exercise price | $ / shares |  |  |  | $ 0.01 |  |  |
Warrant expiration date |  |  |  | Dec. 17, 2019 |  |  |
Issuance of warrant value |  |  |  | $ 2,200,000 |  |  |
Warrants outstanding | shares |  |  |  | 500,000 | 493,145 |  |
Description of warrant |  |  |  |  | Per their terms, the warrants to purchase 500,000 shares of common stock, of which 493,145 remained outstanding at June 30, 2019, may not be exercised if the holder’s ownership of the Company’s common stock would exceed 19.99 percent following such exercise. |  |
Expire on December 17, 2019 | Risk Free Interest Rate |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Warrants outstanding, measurement input |  |  |  | 1.1 |  |  |
Expire on December 17, 2019 | Volatility Percentage |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Warrants outstanding, measurement input |  |  |  | 105.8 |  |  |
Expire on December 17, 2019 | Warrant Term |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Warrant term |  |  |  | 7 years |  |  |
Expire on December 17, 2019 | Dividend Yield |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Warrants outstanding, measurement input |  |  |  | 0 |  |  |
Registration Rights Agreement |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Expiration period |  |  | 10 years |  |  |  |
Maximum amount of expense agreed to bear under the agreement |  |  | $ 50,000 |  |  |  |
Registration Rights Agreement | Baker Brothers Life Sciences L.P. |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Value of shares purchased by Baker Entities in public offerings | $ 200,000,000.0 | $ 43,000,000.0 | $ 75,000,000.0 |  |  |  |
Option To Purchase Additional Shares |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Share of common stock issued | shares | 2,426,470 | 909,090 |  |  |  |  |

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