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Commitments and Contingencies - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended			6 Months Ended
	Aug. 31, 2018	May 31, 2018	Jun. 30, 2019	Sep. 30, 2018	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018	Dec. 31, 2017
Other Commitments [Line Items]
Loss on strategic investment						$ 241,000	$ 247,000
Restricted cash			$ 4,787,000		$ 3,111,000	4,787,000	3,111,000	$ 4,826,000	$ 2,475,000
Letter of Credit | Corporate Credit Card Program
Other Commitments [Line Items]
Restricted cash			2,000,000.0			2,000,000.0
Letter of Credit | Fleet Program
Other Commitments [Line Items]
Restricted cash			400,000			400,000
Other assets
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment			1,100,000			1,100,000		$ 1,300,000
Other expense
Other Commitments [Line Items]
Loss on strategic investment			$ 12,000		$ 200,000	$ 200,000	$ 200,000
Exclusivity Deed | Neuren
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment		$ 3,100,000
Shares subscribed		1,330,000
Exclusivity Deed | Neuren | Selling, general and administrative
Other Commitments [Line Items]
Payments for exclusive right		$ 900,000
License Agreements | Neuren | North America
Other Commitments [Line Items]
Upfront license fee	$ 10,000,000.0
License Agreements | Neuren | Research and development | North America
Other Commitments [Line Items]
Upfront payment				$ 10,000,000.0
Maximum
Other Commitments [Line Items]
Percentage of royalty payments obligation on net product sales						2.00%
Maximum | License Agreements | Neuren | North America
Other Commitments [Line Items]
Additional milestone payments payable	$ 455,000,000.0

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