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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenues
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 83,205	$ 57,063	$ 146,164	$ 105,931
Operating expenses
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Cost of product sales	$ 2,958	$ 3,562	$ 5,908	$ 5,715
License fees and royalties	2,037	1,516	3,667	2,848
Research and development	67,320	46,592	120,243	85,868
Selling, general and administrative	67,981	69,472	161,071	130,398
Total operating expenses	140,296	121,142	290,889	224,829
Loss from operations	(57,091)	(64,079)	(144,725)	(118,898)
Interest income, net	2,527	1,279	5,461	2,449
Other expense	(12)	(247)	(241)	(247)
Loss before income taxes	(54,576)	(63,047)	(139,505)	(116,696)
Income tax expense	365	219	740	866
Net loss	$ (54,941)	$ (63,266)	$ (140,245)	$ (117,562)
Net loss per common share, basic and diluted	$ (0.38)	$ (0.51)	$ (0.97)	$ (0.94)
Weighted average common shares outstanding, basic and diluted	144,314	124,910	144,148	124,819

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