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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Other Comprehensive Income (Loss)
Beginning balance at Dec. 31, 2017 $ 335,285 $ 12 $ 1,559,343 $ (1,223,671) $ (399)
Issuance of common stock from exercise of stock options     3,468    
Issuance of common stock pursuant to employee stockpurchase plan 2,365        
Stock-based compensation     41,265    
Net loss (117,562)     (117,562)  
Other comprehensive income (loss)         (101)
Ending balance at Jun. 30, 2018 264,720 12 1,606,441 (1,341,233) (500)
Beginning balance at Mar. 31, 2018 304,169 12 1,582,823 (1,277,967) (699)
Issuance of common stock from exercise of stock options     588    
Issuance of common stock pursuant to employee stockpurchase plan 2,365        
Stock-based compensation     20,665    
Net loss (63,266)     (63,266)  
Other comprehensive income (loss)         199
Ending balance at Jun. 30, 2018 264,720 12 1,606,441 (1,341,233) (500)
Beginning balance at Dec. 31, 2018 479,079 14 1,948,300 (1,468,863) (372)
Issuance of common stock from exercise of stock options     6,623    
Issuance of common stock pursuant to employee stockpurchase plan 2,199        
Stock-based compensation     40,332    
Net loss (140,245)     (140,245)  
Other comprehensive income (loss)         926
Ending balance at Jun. 30, 2019 388,914 14 1,997,454 (1,609,108) 554
Beginning balance at Mar. 31, 2019 418,356 14 1,972,302 (1,554,167) 207
Issuance of common stock from exercise of stock options     2,447    
Issuance of common stock pursuant to employee stockpurchase plan 2,199        
Stock-based compensation     20,506    
Net loss (54,941)     (54,941)  
Other comprehensive income (loss)         347
Ending balance at Jun. 30, 2019 $ 388,914 $ 14 $ 1,997,454 $ (1,609,108) $ 554