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Stock-Based Compensation - Summary of Stock-based Compensation Expense Included in Statements of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2019 | Sep. 30, 2018 | Sep. 30, 2019 | Sep. 30, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation expense | $ 22,023 | $ 20,169 | $ 62,502 | $ 61,163
Cost of product sales |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation expense | 372 | 838 | 2,344 | 3,025
Research and development |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation expense | 8,680 | 8,066 | 24,461 | 23,617
Selling, general and administrative |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation expense | $ 12,971 | $ 11,265 | $ 35,697 | $ 34,521

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