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Commitments and Contingencies - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended		9 Months Ended
	Aug. 31, 2018	May 31, 2018	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018	Dec. 31, 2017
Other Commitments [Line Items]
(Gain) loss on strategic investment					$ (506,000)	$ 1,967,000
Restricted cash			$ 4,787,000	$ 3,111,000	4,787,000	3,111,000	$ 4,826,000	$ 2,475,000
Letter of Credit | Corporate Credit Card Program
Other Commitments [Line Items]
Restricted cash			2,000,000.0		2,000,000.0
Letter of Credit | Fleet Program
Other Commitments [Line Items]
Restricted cash			400,000		400,000
Other assets
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment			1,800,000		1,800,000		$ 1,300,000
Other expense
Other Commitments [Line Items]
(Gain) loss on strategic investment			$ 700,000	1,700,000	$ 500,000	$ 2,000,000.0
Exclusivity Deed | Neuren
Other Commitments [Line Items]
Aggregate carrying amount of strategic equity investment		$ 3,100,000
Shares subscribed		1,330,000
Exclusivity Deed | Neuren | Selling, general and administrative
Other Commitments [Line Items]
Payments for exclusive right		$ 900,000
License Agreements | Neuren | North America
Other Commitments [Line Items]
Upfront license fee	$ 10,000,000.0
License Agreements | Neuren | Research and development | North America
Other Commitments [Line Items]
Upfront payment				$ 10,000,000.0
Maximum
Other Commitments [Line Items]
Percentage of royalty payments obligation on net product sales					2.00%
Maximum | License Agreements | Neuren | North America
Other Commitments [Line Items]
Additional milestone payments payable	$ 455,000,000.0

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