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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities    
Net loss $ (182,223) $ (179,700)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 62,502 61,163
Amortization of premiums and accretion of discounts on investment securities (3,052) (415)
Amortization of intangible assets 1,108 1,107
(Gain) loss on strategic investment (506) 1,967
Depreciation 1,023 1,116
Loss on disposal of assets   27
Changes in operating assets and liabilities:    
Accounts receivable, net (4,714) (2,615)
Interest and other receivables 234 363
Inventory (426) 1,464
Prepaid expenses (641) (6,494)
Operating lease right-of-use assets 2,856  
Other assets 98 111
Accounts payable 277 (5,856)
Accrued liabilities 3,301 (1,647)
Operating lease liabilities (2,070)  
Long-term liabilities 810 1,018
Net cash used in operating activities (121,423) (128,391)
Cash flows from investing activities    
Purchases of investment securities (260,859) (95,379)
Maturities of investment securities 305,089 217,562
Purchases of strategic investments   (3,150)
Proceeds from sale of property and equipment   5
Purchases of property and equipment (922) (1,578)
Net cash provided by investing activities 43,308 117,460
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 328,789 6,044
Net cash provided by financing activities 328,789 6,044
Effect of exchange rate changes on cash 3 2
Net increase (decrease) in cash, cash equivalents and restricted cash 250,677 (4,885)
Cash, cash equivalents and restricted cash    
Beginning of period 139,584 71,893
End of period 390,261 67,008
Supplemental disclosure of noncash information:    
Property and equipment purchases in accounts payable and accrued liabilities $ 41 $ 280