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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Other Comprehensive Income (Loss)
Beginning balance at Dec. 31, 2017 $ 335,285 $ 12 $ 1,559,343 $ (1,223,671) $ (399)
Issuance of common stock from exercise of stock options     3,679    
Issuance of common stock pursuant to employee stockpurchase plan 2,365        
Stock-based compensation     61,726    
Net loss (179,700)     (179,700)  
Other comprehensive (loss) income         85
Ending balance at Sep. 30, 2018 223,440 12 1,627,113 (1,403,371) (314)
Beginning balance at Jun. 30, 2018 264,720 12 1,606,441 (1,341,233) (500)
Issuance of common stock from exercise of stock options     211    
Stock-based compensation     20,461    
Net loss (62,138)     (62,138)  
Other comprehensive (loss) income         186
Ending balance at Sep. 30, 2018 223,440 12 1,627,113 (1,403,371) (314)
Beginning balance at Dec. 31, 2018 479,079 14 1,948,300 (1,468,863) (372)
Issuance of common stock in public offering, net of issuance costs   1 271,462    
Issuance of common stock from exercise of stock options     55,127    
Issuance of common stock pursuant to employee stockpurchase plan 2,199        
Stock-based compensation     62,852    
Net loss (182,223)     (182,223)  
Other comprehensive (loss) income         792
Ending balance at Sep. 30, 2019 689,289 15 2,339,940 (1,651,086) 420
Beginning balance at Jun. 30, 2019 388,914 14 1,997,454 (1,609,108) 554
Issuance of common stock in public offering, net of issuance costs   1 271,462    
Issuance of common stock from exercise of stock options     48,504    
Stock-based compensation     22,520    
Net loss (41,978)     (41,978)  
Other comprehensive (loss) income         (134)
Ending balance at Sep. 30, 2019 $ 689,289 $ 15 $ 2,339,940 $ (1,651,086) $ 420