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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2015
Income Tax [Line Items] |  |  |  |
State income tax provision | $ 900,000 | $ 1,300,000 | $ 1,100,000 |
Charitable contribution carryforwards | 18,303,000 | $ 8,530,000 |  |
Federal R&D credit carryforwards | 40,400,000 |  |  |
Increase in valuation allowance of deferred tax assets | $ 99,700,000 |  |  |
Tax rate | 21.00% | 21.00% | 35.00% |
Deferred tax asset , Switzerland tax reform | $ 57,000,000.0 |  |  |
Unrecognized tax reserves recorded during period | 1,908,000 | $ 3,104,000 | $ 361,000 |
Interest and/or penalties accrued | 0 | 0 |  |
Tax cuts and jobs act provisional adjustment |  |  | 1,100,000 |
Interest and/or penalties | 0 | $ 0 | $ 0 |
Federal |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 426,100,000 |  |  |
Federal | Expiring in 2025 |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 6,900,000 |  |  |
Federal | Expiring in 2021 |  |  |  |
Income Tax [Line Items] |  |  |  |
Charitable contribution carryforwards |  |  |  | $ 75,800
State |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | $ 363,200,000 |  |  |
Remaining net operating loss carryforward, expiration year | 2026 |  |  |
Research and development credit carryforwards with no expiration date | $ 13,500,000 |  |  |
State | Expiring in 2024 |  |  |  |
Income Tax [Line Items] |  |  |  |
Net operating loss carryforwards with no expiration date | 1,500,000 |  |  |
State | Expiring in 2025 | Maximum |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 100,000 |  |  |
State | Expiring in 2021 |  |  |  |
Income Tax [Line Items] |  |  |  |
Charitable contribution carryforwards |  |  |  | $ 75,800
Foreign |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | $ 1,004,200,000 |  |  |
Remaining net operating loss carryforward, expiration year | 2026 |  |  |
Net operating loss carryforwards with no expiration date | $ 3,400,000 |  |  |
Foreign | Operating Loss Carryforwards Expiring 2022 |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 1,000,900,000 |  |  |
Expire in 2020 |  |  |  |
Income Tax [Line Items] |  |  |  |
Federal R&D credit carryforwards | $ 200,000 |  |  |

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