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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Income Tax Disclosure [Abstract] |  |  |
Amounts computed at statutory federal rate | $ (49,365) | $ (51,226) | $ (98,016)
Stock-based compensation and other permanent differences | 6,070 | 3,432 | 1,341
R&D credits | (16,687) | (7,941) | (5,573)
Change in valuation allowance | 99,846 | 34,333 | (28,230)
State taxes | (2,138) | (1,017) | (26)
Contingencies | 1,861 | 2,938 | 360
Foreign rate differential | 20,413 | 20,896 | 61,480
Tax Cuts and Jobs Act |  |  | 68,889
Switzerland Tax Reform | (59,181) |  |
Other | 57 | (159) | 894
Income tax expense | $ 876 | $ 1,256 | $ 1,119

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