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Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019		Dec. 31, 2018		Dec. 31, 2017
Revenues
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Total revenues	$ 339,076		$ 223,807		$ 124,901
Operating expenses
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Cost of product sales	$ 11,344		$ 12,377		$ 9,077
License fees and royalties	8,254		5,953		3,983
Research and development	240,385		187,163		149,189
Selling, general and administrative	325,638		265,758		255,062
Total operating expenses	585,621		471,251		417,311
Loss from operations	(246,545)		(247,444)		(292,410)
Interest income, net	11,165		5,348		4,126
Other income (expense)	997		(1,840)
Loss before income taxes	(234,383)		(243,936)		(288,284)
Income tax expense	876		1,256		1,119
Net loss	$ (235,259)		$ (245,192)		$ (289,403)
Net loss per common share, basic and diluted	$ (1.60)	[1]	$ (1.94)	[1]	$ (2.36)
Weighted average common shares outstanding, basic and diluted	147,199		126,583		122,600
[1] Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.

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