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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2019	Dec. 31, 2018
Deferred tax assets
NOL carryforwards	$ 182,948	$ 170,476
R&D credit carryforwards	48,069	32,984
Capitalized R&D	7,607	7,421
Stock-based compensation	45,440	45,492
Intangibles	59,783
Charitable contribution carryforwards	18,303	8,530
Lease liabilities	2,366
Other	8,568	6,220
Total deferred tax assets	373,084	271,123
Valuation allowance	(370,783)	$ (271,123)
Deferred tax liabilities
Right-of-use assets	(2,301)
Total deferred tax liabilities	$ (2,301)

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