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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (49,365)	$ (51,226)	$ (98,016)
Stock-based compensation and other permanent differences	6,070	3,432	1,341
R&D credits	(16,687)	(7,941)	(5,573)
Change in valuation allowance	99,846	34,333	(28,230)
State taxes	(2,138)	(1,017)	(26)
Contingencies	1,861	2,938	360
Foreign rate differential	20,413	20,896	61,480
Tax Cuts and Jobs Act			68,889
Switzerland Tax Reform	(59,181)
Other	57	(159)	894
Income tax expense	$ 876	$ 1,256	$ 1,119

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