Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Cash flows from operating activities
Net loss	$ (235,259)	$ (245,192)	$ (289,403)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	82,265	81,564	75,532
Amortization of premiums and accretion of discounts on investment securities	(3,613)	(578)	(291)
Amortization of intangible assets	1,477	1,476	1,477
(Gain) loss on strategic investment	(997)	1,840
Depreciation	1,289	1,529	1,236
Loss on disposal of assets	3	88	4
Changes in operating assets and liabilities:
Accounts receivable, net	(9,691)	(8,747)	(11,440)
Interest and other receivables	(394)	(612)	150
Inventory	(1,737)	1,926	(1,012)
Prepaid expenses and other current assets	2,121	(12,270)	(911)
Operating lease right-of-use assets	3,875
Other assets	39	(236)	431
Accounts payable	4,055	(5,619)	4,874
Accrued liabilities	6,458	15,994	4,206
Deferred revenue			(2,644)
Operating lease liabilities	(2,518)
Long-term liabilities	1,497	1,367	34
Net cash used in operating activities	(151,130)	(167,470)	(217,757)
Cash flows from investing activities
Purchases of investment securities	(578,634)	(327,914)	(478,818)
Maturities of investment securities	413,927	261,678	572,103
Purchases of strategic investments		(3,149)
Proceeds from sale of property and equipment		44
Purchases of property and equipment	(1,129)	(2,148)	(812)
Net cash (used in) provided by investing activities	(165,836)	(71,489)	92,473
Cash flows from financing activities
Proceeds from issuance of common stock, net of issuance costs	371,847	306,647	31,188
Net cash provided by financing activities	371,847	306,647	31,188
Effect of exchange rate changes on cash	2	3	(6)
Net increase (decrease) in cash, cash equivalents and restricted cash	54,883	67,691	(94,102)
Cash, cash equivalents and restricted cash
Beginning of period	139,584	71,893	165,995
End of period	194,467	139,584	71,893
Supplemental disclosure of cash flow information:
Cash paid for income taxes	1,597	1,261	1,367
Supplemental disclosure of noncash information:
Property and equipment purchases in accounts payable and accrued liabilities	$ 34	$ 160	$ 9

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