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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities    
Net loss $ (88,023) $ (85,304)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 22,348 19,883
Amortization of premiums and accretion of discounts on investment securities 87 (1,006)
Amortization of intangible assets 370 370
Loss on strategic investment 1,497 229
Depreciation 294 415
Changes in operating assets and liabilities:    
Accounts receivable, net (5,855) (3,868)
Interest and other receivables (842) (2,113)
Inventory (37) (557)
Prepaid expenses (3,520) (3,015)
Operating lease right-of-use assets 1,187 833
Other assets 18 105
Accounts payable (599) 108
Accrued liabilities 24,057 11,035
Operating lease liabilities (360) (938)
Long-term liabilities 376 (352)
Net cash used in operating activities (49,002) (64,175)
Cash flows from investing activities    
Purchases of investment securities (100,773) (73,945)
Maturities of investment securities 131,315 97,525
Purchases of property and equipment (934) (822)
Net cash provided by investing activities 29,608 22,758
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 3,754 4,176
Net cash provided by financing activities 3,754 4,176
Effect of exchange rate changes on cash 2 1
Net decrease in cash, cash equivalents and restricted cash (15,638) (37,240)
Cash, cash equivalents and restricted cash    
Beginning of period 194,467 139,584
End of period 178,829 102,344
Supplemental disclosure of noncash information:    
Property and equipment purchases in accounts payable and accrued liabilities $ 1,269 $ 21