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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 110,103 $ 83,205 $ 200,171 $ 146,164
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,899 $ 2,958 $ 5,698 $ 5,908
License fees and royalties 2,575 2,037 4,750 3,667
Research and development 64,295 67,320 136,931 120,243
Selling, general and administrative 84,344 67,981 186,317 161,071
Total operating expenses 154,113 140,296 333,696 290,889
Loss from operations (44,010) (57,091) (133,525) (144,725)
Interest income, net 1,825 2,527 4,814 5,461
Other income (expense) 437 (12) (1,060) (241)
Loss before income taxes (41,748) (54,576) (129,771) (139,505)
Income tax expense 393 365 393 740
Net loss $ (42,141) $ (54,941) $ (130,164) $ (140,245)
Net loss per common share, basic and diluted $ (0.27) $ (0.38) $ (0.83) $ (0.97)
Weighted average common shares outstanding, basic and diluted 156,535 144,314 155,951 144,148