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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 120,577 $ 94,586 $ 320,748 $ 240,750
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,005 $ 2,416 $ 7,703 $ 8,324
License fees and royalties 2,796 2,273 7,546 5,940
Research and development 120,083 62,622 257,014 182,865
Selling, general and administrative 81,592 72,696 267,909 233,767
Total operating expenses 206,476 140,007 540,172 430,896
Loss from operations (85,899) (45,421) (219,424) (190,146)
Interest income, net 1,242 2,432 6,056 7,893
Other (expense) income (202) 747 (1,262) 506
Loss before income taxes (84,859) (42,242) (214,630) (181,747)
Income tax expense (199) (264) 194 476
Net loss $ (84,660) $ (41,978) $ (214,824) $ (182,223)
Net loss per common share, basic and diluted $ (0.54) $ (0.29) $ (1.37) $ (1.26)
Weighted average common shares outstanding, basic and diluted 158,129 145,906 156,683 144,741