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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities    
Net loss $ (214,824) $ (182,223)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 63,227 62,502
Amortization of premiums and accretion of discounts on investment securities 821 (3,052)
Amortization of intangible assets 1,108 1,108
Loss (gain) on strategic investment 1,262 (506)
Loss on disposal of assets 281  
Depreciation 986 1,023
Non-cash in-process research and development 44,280  
Changes in operating assets and liabilities:    
Accounts receivable, net (10,563) (4,714)
Interest and other receivables 653 234
Inventory (1,671) (426)
Prepaid expenses (11,403) (641)
Operating lease right-of-use assets 2,863 2,856
Other assets 50 98
Accounts payable (3,751) 277
Accrued liabilities 17,853 3,301
Operating lease liabilities (587) (2,070)
Long-term liabilities 737 810
Net cash used in operating activities (108,678) (121,423)
Cash flows from investing activities    
Purchases of investment securities (100,808) (260,859)
Maturities of investment securities 415,863 305,089
Purchases of property and equipment (5,588) (922)
Net cash provided by investing activities 309,467 43,308
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 62,870 328,789
Net cash provided by financing activities 62,870 328,789
Effect of exchange rate changes on cash (4) 3
Net increase in cash, cash equivalents and restricted cash 263,655 250,677
Cash, cash equivalents and restricted cash    
Beginning of period 194,467 139,584
End of period 458,122 390,261
Supplemental disclosure of noncash information:    
Common stock issued in connection with merger agreement 44,280  
Property and equipment purchases in accounts payable and accrued liabilities $ 926 $ 41