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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Income Tax [Line Items] |  |  |  |
State income tax provision | $ 400,000 | $ 900,000 | $ 1,300,000 |
Foreign Income Tax Expense (Benefit) | 200,000 |  |  |
Charitable contribution carryforwards | 28,470,000 | 18,303,000 |  |
Federal R&D credit carryforwards | 55,500,000 |  |  |
Increase in valuation allowance of deferred tax assets | 9,800,000 |  |  |
Limitation on the utilization of NOLs, percentage |  |  |  | 80.00%
Deferred tax asset , Switzerland tax reform | 52,800,000 | 57,000,000.0 |  |
Unrecognized tax reserves recorded during period | 2,900,000 | 1,900,000 | 3,100,000 |
Interest and/or penalties accrued | 0 | 0 |  |
Interest and/or penalties | 0 | $ 0 | $ 0 |
Federal |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 539,200,000 |  |  |
Federal | Expiring in 2025 |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 6,900,000 |  |  |
Federal | Expiring in 2021 |  |  |  |
Income Tax [Line Items] |  |  |  |
Charitable contribution carryforwards | 120,800 |  |  |
State |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | $ 416,300,000 |  |  |
Remaining net operating loss carryforward, expiration year | 2026 |  |  |
Research and development credit carryforwards with no expiration date | $ 16,500,000 |  |  |
State | Expiring in 2024 |  |  |  |
Income Tax [Line Items] |  |  |  |
Net operating loss carryforwards with no expiration date | 2,600,000 |  |  |
State | Expiring in 2025 | Maximum |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 100,000 |  |  |
State | Expiring in 2021 |  |  |  |
Income Tax [Line Items] |  |  |  |
Charitable contribution carryforwards | 120,800 |  |  |
Foreign |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | $ 1,186,500,000 |  |  |
Remaining net operating loss carryforward, expiration year | 2026 |  |  |
Net operating loss carryforwards with no expiration date | $ 3,700,000 |  |  |
Foreign | Operating Loss Carryforwards Expiring 2022 |  |  |  |
Income Tax [Line Items] |  |  |  |
Operating loss carryforwards | 1,186,500,000 |  |  |
Expire in 2021 |  |  |  |
Income Tax [Line Items] |  |  |  |
Federal R&D credit carryforwards | $ 200,000 |  |  |

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