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Summary of Significant Accounting Policies - Summary of Stock-based Compensation Expense Included in Statements of Operations (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | $ 84,422 | $ 82,265 | $ 81,564
Cost of product sales |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | 2,632 | 2,936 | 3,863
Research and development |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | 31,314 | 32,533 | 32,038
Sales, general and administrative |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | $ 50,476 | $ 46,796 | $ 45,663

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