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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2020
Accounting Policies [Abstract] |
Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash | The following table provides a reconciliation of cash, cash equivalents and restricted cash reported in the consolidated balance sheets that sum to the total of the same such amounts shown in the Consolidated Statements of Cash Flows (in thousands).
|  | Twelve Months Ended December 31, 2020 |  |  | Twelve Months Ended December 31, 2019 |
|  | Beginning of period |  |  | End of period |  |  | Beginning of period |  |  | End of period |
Cash and cash equivalents |  | $ | 189,680 |  |  | $ | 326,028 |  |  | $ | 134,758 |  |  | $ | 189,680 |
Restricted cash |  |  | 4,787 |  |  |  | 5,770 |  |  |  | 4,826 |  |  |  | 4,787 |
Total cash, cash equivalents and restricted cash shown in the statements of cash flows |  | $ | 194,467 |  |  | $ | 331,798 |  |  | $ | 139,584 |  |  | $ | 194,467 |
Schedule of Estimated Useful Lives by Major Asset Category | Property and equipment are recorded at cost and depreciated over their estimated useful lives using the straight-line method. Leasehold improvements are amortized over the shorter of their estimated useful lives or the term of the lease by use of the straight-line method. Construction-in-process reflects amounts incurred for property, equipment or improvements that have not been placed in service. Maintenance and repair costs are expensed as incurred. When assets are retired or sold, the assets and accumulated depreciation are removed from the respective accounts and any gain or loss is recognized. Estimated useful lives by major asset category are as follows:
|  | Useful Lives
Machinery and equipment |  | 5 to 7 years
Computers and software |  | 3 years
Furniture and fixtures |  | 10 years
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Options | The estimated fair value of each stock option and purchase right is then expensed over the requisite service period, which is generally the vesting period. The following weighted-average assumptions were used during these periods:
|  | Years Ended December 31, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Stock Options: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  |  | 63 | % |  |  | 62 | % |  |  | 71 | %
Risk-free interest rate |  |  | 1 | % |  |  | 2 | % |  |  | 3 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life of options in years |  |  | 5.5 |  |  |  | 5.7 |  |  |  | 5.7 |
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Purchase Plan Rights |
|  | Years Ended December 31, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Employee Stock Purchase Plan: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  | 50%-76% |  |  | 62%-86% |  |  | 59%-79% |
Risk-free interest rate |  | 0.1%-0.2% |  |  | 1.5%-2.4% |  |  | 2.1%-2.8% |
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life in years |  | 0.5-2.0 |  |  | 0.5-2.0 |  |  | 0.5-2.0 |
Summary of Stock-based Compensation Expense Included in Statements of Operations | The table below summarizes the total stock-based compensation expense included in the Company’s statements of operations for the periods presented (in thousands):
|  | Years Ended December 31, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Cost of product sales |  | $ | 2,632 |  |  | $ | 2,936 |  |  | $ | 3,863 |
Research and development |  |  | 31,314 |  |  |  | 32,533 |  |  |  | 32,038 |
Sales, general and administrative |  |  | 50,476 |  |  |  | 46,796 |  |  |  | 45,663 |
|  | $ | 84,422 |  |  | $ | 82,265 |  |  | $ | 81,564 |

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