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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets |  |
NOL carryforwards | $ 218,905 | $ 182,948
R&D credit carryforwards | 63,886 | 48,069
Stock-based compensation | 47,547 | 45,440
Charitable contributions | 28,470 | 18,303
Lease liabilities | 11,675 | 2,366
Intangibles | 7,109 | 59,783
Capitalized R&D | 6,073 | 7,607
Other | 9,390 | 8,773
Total deferred tax assets | 393,055 | 373,289
Valuation allowance | (380,533) | (370,783)
Deferred tax liabilities |  |
Right-of-use assets | (11,142) | (2,301)
Propery and equipment | (1,380) | (205)
Total deferred tax liabilities | $ (12,522) | $ (2,506)

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