XML 21 R4.htm IDEA: XBRL DOCUMENT v3.20.4
Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues      
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 441,755 $ 339,076 $ 223,807
Operating expenses      
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 10,211 $ 11,344 $ 12,377
License fees and royalties 10,339 8,254 5,953
Research and development 319,130 240,385 187,163
Selling, general and administrative 388,661 325,638 265,758
Total operating expenses 728,341 585,621 471,251
Loss from operations (286,586) (246,545) (247,444)
Interest income, net 6,610 11,165 5,348
Other (expense) income (997) 997 (1,840)
Loss before income taxes (280,973) (234,383) (243,936)
Income tax expense 611 876 1,256
Net loss $ (281,584) $ (235,259) $ (245,192)
Net loss per common share, basic and diluted $ (1.79) [1] $ (1.60) [1] $ (1.94)
Weighted average common shares outstanding, basic and diluted 157,331 147,199 126,583
[1] Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.