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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (59,004)	$ (49,365)	$ (51,226)
Stock-based compensation and other permanent differences	991	5,691	3,379
Write-off of IP R&D	9,565
R&D credits	(17,909)	(16,687)	(7,941)
Change in valuation allowance	5,925	99,846	34,333
State taxes	(5,038)	(2,138)	(1,017)
Contingencies	2,665	1,861	2,938
Foreign rate differential	4,208	20,413	20,896
Limitation on executive compensation	3,705	1,178	53
Deferred rate adjustment	2,130
Switzerland tax reform	53,045	(59,181)
Other	328	(742)	(159)
Income tax expense	$ 611	$ 876	$ 1,256

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