XML 23 R6.htm IDEA: XBRL DOCUMENT v3.20.4
Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Cash flows from operating activities      
Net loss $ (281,584) $ (235,259) $ (245,192)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation 84,422 82,265 81,564
Amortization of premiums and accretion of discounts on investment securities 1,470 (3,613) (578)
Amortization of intangible assets 1,477 1,477 1,476
Loss (gain) on strategic investment 997 (997) 1,840
Depreciation 1,455 1,289 1,529
Loss on disposal of assets 281 3 88
Non-cash in-process research and development 44,280    
Changes in operating assets and liabilities:      
Accounts receivable, net (12,466) (9,691) (8,747)
Interest and other receivables 58 (394) (612)
Inventory (3,320) (1,737) 1,926
Prepaid expenses and other current assets (7,088) 2,121 (12,270)
Operating lease right-of-use assets 4,280 3,875  
Other assets 182 39 (236)
Accounts payable 1,271 4,055 (5,619)
Accrued liabilities 27,569 6,458 15,994
Operating lease liabilities (1,769) (2,518)  
Long-term liabilities 2,319 1,497 1,367
Net cash used in operating activities (136,166) (151,130) (167,470)
Cash flows from investing activities      
Purchases of investment securities (339,908) (578,634) (327,914)
Maturities of investment securities 540,004 413,927 261,678
Purchases of strategic investments     (3,149)
Net purchases of property and equipment (7,587) (1,129) (2,104)
Net cash provided by (used in) investing activities 192,509 (165,836) (71,489)
Cash flows from financing activities      
Proceeds from issuance of common stock, net of issuance costs 80,996 371,847 306,647
Net cash provided by financing activities 80,996 371,847 306,647
Effect of exchange rate changes on cash (8) 2 3
Net increase in cash, cash equivalents and restricted cash 137,331 54,883 67,691
Cash, cash equivalents and restricted cash      
Beginning of period 194,467 139,584 71,893
End of period 331,798 194,467 139,584
Supplemental disclosure of cash flow information:      
Cash paid for income taxes 1,113 1,597 1,261
Supplemental disclosure of noncash information:      
Property and equipment purchases in accounts payable and accrued liabilities 130 $ 34 $ 160
Value of common stock issued in connection with asset acquisition $ 44,280