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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance at Dec. 31, 2017 $ 335,285 $ 12 $ 1,559,343 $ (1,223,671) $ (399)
Beginning balance (in shares) at Dec. 31, 2017   124,410,552      
Issuance of common stock in public offering, net of issuance costs 298,537 $ 2 298,535    
Issuance of common stock in public offering, net of issuance costs (in shares)   18,602,941      
Issuance of common stock from exercise of stock options 4,428   4,428    
Issuance of common stock from exercise of stock options (in shares)   599,529      
Issuance of common stock pursuant to employee stock purchase plan 3,682   3,682    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   233,720      
Issuance of common stock from exercise of warrants on a net issuance basis (in shares)   6,855      
Net loss (245,192)     (245,192)  
Stock-based compensation 82,312   82,312    
Other comprehensive income 27       27
Ending balance at Dec. 31, 2018 479,079 $ 14 1,948,300 (1,468,863) (372)
Ending balance (in shares) at Dec. 31, 2018   143,853,597      
Issuance of common stock in public offering, net of issuance costs 271,452 $ 1 271,451    
Issuance of common stock in public offering, net of issuance costs (in shares)   7,187,500      
Issuance of common stock from exercise of stock options and units 95,984   95,984    
Issuance of common stock from exercise of stock options and units (in shares)   3,965,166      
Issuance of common stock pursuant to employee stock purchase plan 4,411   4,411    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   269,037      
Net loss (235,259)     (235,259)  
Stock-based compensation 82,799   82,799    
Other comprehensive income 669       669
Ending balance at Dec. 31, 2019 699,135 $ 15 2,402,945 (1,704,122) 297
Ending balance (in shares) at Dec. 31, 2019   155,275,300      
Issuance of common stock in connection with asset acquisition $ 44,280   44,280    
Issuance of common stock in connection with asset acquisition, Shares   1,156,626      
Issuance of common stock from exercise of stock options (in shares) 2,571,633        
Issuance of common stock from exercise of stock options and units $ 73,834 $ 1 73,833    
Issuance of common stock from exercise of stock options and units (in shares)   2,827,586      
Issuance of common stock pursuant to employee stock purchase plan 7,162   7,162    
Issuance of common stock pursuant to employee stock purchase plan (in shares)   378,259      
Net loss (281,584)     (281,584)  
Stock-based compensation 84,443   84,443    
Other comprehensive income (261)       (261)
Ending balance at Dec. 31, 2020 $ 627,009 $ 16 $ 2,612,663 $ (1,985,706) $ 36
Ending balance (in shares) at Dec. 31, 2020   159,637,771