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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Revenues    
Type of Revenue [Extensible List]   us-gaap:ProductMember
Total revenues $ 106,554 $ 90,068
Operating expenses    
Type of Cost, Good or Service [Extensible List]   us-gaap:ProductMember
Cost of product sales 2,185 $ 2,799
License fees and royalties 2,507 2,175
Research and development 56,973 72,636
Selling, general and administrative 111,661 101,973
Total operating expenses 173,326 179,583
Loss from operations (66,772) (89,515)
Interest income, net 200 2,989
Other income (expense) 145 (1,497)
Loss before income taxes (66,427) (88,023)
Income tax expense 21  
Net loss $ (66,448) $ (88,023)
Net loss per common share, basic and diluted $ (0.42) $ (0.57)
Weighted average common shares outstanding, basic and diluted 160,011 155,368