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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 115,221 $ 110,103 $ 221,775 $ 200,171
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,526 $ 2,899 $ 4,711 $ 5,698
License fees and royalties 2,680 2,575 5,187 4,750
Research and development 56,935 64,295 113,908 136,931
Selling, general and administrative 96,789 84,344 208,450 186,317
Total operating expenses 158,930 154,113 332,256 333,696
Loss from operations (43,709) (44,010) (110,481) (133,525)
Interest income, net 133 1,825 333 4,814
Other income (expense) 178 437 323 (1,060)
Loss before income taxes (43,398) (41,748) (109,825) (129,771)
Income tax expense 473 393 494 393
Net loss $ (43,871) $ (42,141) $ (110,319) $ (130,164)
Net loss per common share, basic and diluted $ (0.27) $ (0.27) $ (0.69) $ (0.83)
Weighted average common shares outstanding, basic and diluted 160,421 156,535 160,217 155,951