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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities    
Net loss $ (124,776) $ (214,824)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 50,735 63,227
Amortization of premiums and accretion of discounts on investment securities 1,766 821
Amortization of intangible assets 1,108 1,108
(Gain) loss on strategic investment (706) 1,262
Loss on disposal of assets   281
Depreciation 1,701 986
Non-cash in-process research and development   44,280
Changes in operating assets and liabilities:    
Accounts receivable, net (12,449) (10,563)
Interest and other receivables 1,063 653
Inventory (4,427) (1,671)
Prepaid expenses 1,072 (11,403)
Operating lease right-of-use assets 4,794 2,863
Other assets 11 50
Accounts payable (771) (3,751)
Accrued liabilities (17,260) 17,853
Operating lease liabilities (4,044) (587)
Long-term liabilities (357) 737
Net cash used in operating activities (102,540) (108,678)
Cash flows from investing activities    
Purchases of investment securities (453,847) (100,808)
Maturities of investment securities 312,317 415,863
Purchases of property and equipment (1,121) (5,588)
Net cash (used in) provided by investing activities (142,651) 309,467
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 13,797 62,870
Net cash provided by financing activities 13,797 62,870
Effect of exchange rate changes on cash 6 (4)
Net (decrease) increase in cash, cash equivalents and restricted cash (231,388) 263,655
Cash, cash equivalents and restricted cash    
Beginning of period 331,798 194,467
End of period $ 100,410 458,122
Supplemental disclosure of noncash information:    
Common stock issues in connection with merger agreement   44,280
Property and equipment purchases in accounts payable and accrued liabilities   $ 926