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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 131,612 $ 120,577 $ 353,387 $ 320,748
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 3,688 $ 2,005 $ 8,399 $ 7,703
License fees and royalties 2,994 2,796 8,181 7,546
Research and development 58,565 120,083 172,473 257,014
Selling, general and administrative 81,666 81,592 290,116 267,909
Total operating expenses 146,913 206,476 479,169 540,172
Loss from operations (15,301) (85,899) (125,782) (219,424)
Interest income, net 129 1,242 462 6,056
Other income (expense) 383 (202) 706 (1,262)
Loss before income taxes (14,789) (84,859) (124,614) (214,630)
Income tax expense (332) (199) 162 194
Net loss $ (14,457) $ (84,660) $ (124,776) $ (214,824)
Net loss per common share, basic and diluted $ (0.09) $ (0.54) $ (0.78) $ (1.37)
Weighted average common shares outstanding, basic and diluted 160,663 158,129 159,651 156,683