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Commitments and Contingencies - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Aug. 31, 2020 | Mar. 31, 2020 | Aug. 31, 2018 | May 31, 2018 | Sep. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2016
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on strategic investment |  |  |  |  |  |  | $ 2,329,000 | $ (997,000) | $ 997,000 |  |
Restricted cash |  |  |  |  |  |  | 5,770,000 | 5,770,000 | 4,787,000 |  |
Corporate Credit Card Program | Letter of Credit |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  |  |  |  |  |  |  |  |  | $ 2,000,000.0
Fleet Program | Letter of Credit |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  |  |  |  |  | 400,000 |  |  |  |
Other assets |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Aggregate carrying amount of strategic equity investment |  |  |  |  |  |  | 3,600,000 | 1,300,000 |  |  |
Other expense |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on strategic investment |  |  |  |  |  |  | 2,300 |  | 1,000,000.0 |  |
Cersci Therapeutics |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront consideration and transaction costs | $ 52,800,000 |  |  |  |  |  |  |  |  |  |
Upfront payment | $ 44,300,000 |  |  |  |  |  |  |  |  |  |
Upfront payment conditions | The Company incurred an aggregate of $52.8 million in upfront consideration and transaction costs, of which, $44.3 million was paid through the issuance of approximately 1.2 million shares of the Company’s common stock. |  |  |  |  |  |  |  |  |  |
Common stock issuance | 1,200,000 |  |  |  |  |  |  |  |  |  |
Cersci Therapeutics | Research and development |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Assets acquisition and upfront payment |  |  |  |  | $ 45,700,000 |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  | 11,000,000.0 | $ 72,700,000 | $ 1,400,000 |  |
Mile stone payments payable |  |  | $ 10,000,000.0 |  |  |  |  |  |  |  |
Milestone payment may be due |  |  |  |  |  |  | $ 10,000,000.0 |  |  |  |
License Agreements | North America |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  |  | 40,000,000.0 |  |  |  |  |  |  |  |
License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  | $ 10,000,000.0 |  |  |  |  |  |  |  |  |
Upfront license fee |  |  | 10,000,000.0 |  |  |  |  |  |  |  |
License Agreements | Neuren | Research and development | North America |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  | $ 10,000,000.0 |  |  |  | $ 10,000,000.0 |
Exclusivity Deed | Neuren |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Aggregate carrying amount of strategic equity investment |  |  |  | $ 3,100,000 |  |  |  |  |  |  |
Shares subscribed |  |  |  | 1,330,000 |  |  |  |  |  |  |
Exclusivity Deed | Neuren | Sales, general and administrative |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payments for exclusive right |  |  |  | $ 900,000 |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty payments obligation on net product sales |  |  |  |  |  |  | 2.00% |  |  |  |
Mile stone payments payable |  |  |  |  |  |  | $ 2,200,000,000 |  |  |  |
Maximum | Cersci Therapeutics | Development Commercialization and Sales Milestones |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Compensation expense related to mergers to former holders | $ 887,000,000.0 |  |  |  |  |  |  |  |  |  |
Maximum | License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  | $ 515,000,000.0 | $ 455,000,000.0 |  |  | $ 515,000,000.0 |  |  |  |  |

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