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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities |  |  |
Net loss | $ (167,870) | $ (281,584) | $ (235,259)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 63,615 | 84,422 | 82,265
Amortization of premiums and accretion of discounts on investment securities | 2,404 | 1,470 | (3,613)
Amortization of intangible assets | 1,108 | 1,477 | 1,477
(Gain) loss on strategic investment | (2,329) | 997 | (997)
Depreciation | 2,236 | 1,455 | 1,289
Loss on disposal of assets | 0 | 281 | 3
Non-cash in-process research and development | 0 | 44,280 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | (16,119) | (12,466) | (9,691)
Interest and other receivables | 1,057 | 58 | (394)
Inventory | (4,210) | (3,320) | (1,737)
Prepaid expenses and other current assets | 1,802 | (7,088) | 2,121
Operating lease right-of-use assets | 6,287 | 4,280 | 3,875
Other assets | 10 | 182 | 39
Accounts payable | (1,617) | 1,271 | 4,055
Accrued liabilities | (8,455) | 27,569 | 6,458
Operating lease liabilities | (5,433) | (1,769) | (2,518)
Long-term liabilities | 1,854 | 2,319 | 1,497
Net cash used in operating activities | (125,660) | (136,166) | (151,130)
Cash flows from investing activities |  |  |
Purchases of investment securities | (492,797) | (339,908) | (578,634)
Maturities of investment securities | 422,817 | 540,004 | 413,927
Net purchases of property and equipment | (1,122) | (7,587) | (1,129)
Net cash (used in) provided by investing activities | (71,102) | 192,509 | (165,836)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 18,162 | 80,996 | 371,847
Net cash provided by financing activities | 18,162 | 80,996 | 371,847
Effect of exchange rate changes on cash | 7 | (8) | 2
Net (decrease) increase in cash, cash equivalents and restricted cash | (178,593) | 137,331 | 54,883
Cash, cash equivalents and restricted cash |  |  |
Beginning of period | 331,798 | 194,467 | 139,584
End of period | 153,205 | 331,798 | 194,467
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 1,038 | 1,113 | 1,597
Supplemental disclosure of noncash information: |  |  |
Property and equipment purchases in accounts payable and accrued liabilities | 0 | 130 | $ 34
Value of common stock issued in connection with asset acquisition | $ 0 | $ 44,280 |

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