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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets |  |
NOL carryforwards | $ 229,476 | $ 218,905
R&D credit carryforwards | 74,702 | 63,886
Stock-based compensation | 51,170 | 47,547
Charitable contributions | 41,355 | 28,470
Lease liabilities | 15,550 | 11,675
Intangibles | 6,741 | 7,109
Capitalized R&D |  | 6,073
Other | 11,700 | 9,390
Total deferred tax assets | 430,694 | 393,055
Valuation allowance | (416,630) | (380,533)
Deferred tax liabilities |  |
Right-of-use assets | (14,063) | (11,142)
Propery and equipment | (1) | (1,380)
Total deferred tax liabilities | (14,064) | (12,522)
Total net deferred tax assets | $ 0 | $ 0

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