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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Income Tax [Line Items] |  |  |
Operating loss carryforwards | $ 100,000 |  |
State income tax provision | 400,000 | $ 400,000 | $ 900,000
Foreign Income Tax Expense (Benefit) |  | 200,000 |
Charitable contribution carryforwards | 41,355,000 | 28,470,000 |
Federal R&D credit carryforwards | 65,800,000 |  |
Increase in valuation allowance of deferred tax assets | 36,100,000 |  |
Deferred tax asset , Switzerland tax reform |  |  | 57,000,000.0
Unrecognized tax reserves recorded during period | 4,100,000 | 2,900,000 | 1,900,000
Interest and/or penalties accrued | 0 | 0 |
Interest and/or penalties | 0 | $ 0 | $ 0
Expire in 2022 |  |  |
Income Tax [Line Items] |  |  |
Federal R&D credit carryforwards | 300,000 |  |
Federal |  |  |
Income Tax [Line Items] |  |  |
Operating loss carryforwards | 551,200,000 |  |
Federal | Expiring in 2025 |  |  |
Income Tax [Line Items] |  |  |
Operating loss carryforwards | 6,900,000 |  |
State |  |  |
Income Tax [Line Items] |  |  |
Operating loss carryforwards | 426,200,000 |  |
Remaining net operating loss carryforward, expiration year |  | 2026 |
Charitable contribution carryforwards | 171,300,000 |  |
Research and development credit carryforwards with no expiration date | 18,500,000 |  |
State | Expiring in 2024 |  |  |
Income Tax [Line Items] |  |  |
Net operating loss carryforwards with no expiration date | 2,800,000 |  |
State | Expiring in 2022 |  |  |
Income Tax [Line Items] |  |  |
Charitable contribution carryforwards | 21,800,000 |  |
Foreign |  |  |
Income Tax [Line Items] |  |  |
Operating loss carryforwards | 1,354,300,000 |  |
Remaining net operating loss carryforward, expiration year |  | 2026 |
Net operating loss carryforwards with no expiration date | 3,400,000 |  |
Foreign | Operating Loss Carryforwards Expiring 2022 |  |  |
Income Tax [Line Items] |  |  |
Operating loss carryforwards | $ 218,500,000 |  |

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