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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues      
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 484,145 $ 441,755 $ 339,076
Operating expenses      
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 10,843 $ 10,211 $ 11,344
License fees and royalties 8,298 10,339 8,254
Research and development 239,415 319,130 240,385
Selling, general and administrative 396,028 388,661 325,638
Total operating expenses 654,584 728,341 585,621
Loss from operations (170,439) (286,586) (246,545)
Interest income, net 591 6,610 11,165
Other income (expense) (2,329) (997) 997
Loss before income taxes (167,519) (280,973) (234,383)
Income tax expense 351 611 876
Net loss $ (167,870) $ (281,584) $ (235,259)
Net loss per common share, basic and diluted $ (1.05) [1] $ (1.79) [1] $ (1.60)
Weighted average common shares outstanding, basic and diluted 160,493 157,331 147,199
[1] Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.