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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (35,179)	$ (59,004)	$ (49,365)
Stock-based compensation and other permanent differences	6,696	991	5,691
Write-off of IP R&D	1,277	9,565
R&D credits	(11,727)	(17,909)	(16,687)
Change in valuation allowance	36,099	5,925	99,846
State taxes	(2,617)	(5,038)	(2,138)
Contingencies	3,879	2,665	1,861
Foreign rate differential	2,857	4,208	20,413
Limitation on executive compensation	1,808	3,705	1,178
Deferred rate adjustment	(2,424)	2,130
Switzerland tax reform	(923)	53,045	(59,181)
Other	605	328	(742)
Income tax expense	$ 351	$ 611	$ 876

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