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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenues    
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 115,468 $ 106,554
Operating expenses    
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,950 $ 2,185
License fees and royalties 0 2,507
Research and development 128,855 56,973
Selling, general and administrative 96,679 111,661
Total operating expenses 228,484 173,326
Loss from operations (113,016) (66,772)
Interest income, net 105 200
Other income (expense) 340 (145)
Loss before income taxes (112,571) (66,427)
Income tax expense 485 21
Net loss $ (113,056) $ (66,448)
Net loss per common share, basic and diluted $ (0.70) $ (0.42)
Weighted average common shares outstanding, basic and diluted 161,231 160,011