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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands, shares in Millions | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Jan. 31, 2022 | Aug. 31, 2020 | Mar. 31, 2020 | Aug. 31, 2018 | Jun. 30, 2022 | Jun. 30, 2021 | Sep. 30, 2020 | Mar. 31, 2020 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2018 | Dec. 31, 2021 | Dec. 31, 2020
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on strategic investment |  |  |  |  |  |  |  |  | $ (158) | $ 323 |  |  |
Research and development |  |  |  |  | $ 75,646 | $ 56,935 |  |  | 204,501 | 113,908 |  |  |
Restricted cash |  |  |  |  | 5,770 | $ 5,770 |  |  | 5,770 | $ 5,770 |  | $ 5,770 | $ 5,770
Letter of Credit | Corporate Credit Card Program |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  |  |  | 2,000 |  |  |  | 2,000 |  |  |  |
Letter of Credit | Fleet Program |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  |  |  | 400 |  |  |  | 400 |  |  |  |
Cersci Therapeutics |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront consideration and transaction costs |  | $ 52,800 |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  | $ 44,300 |  |  |  |  |  |  |  |  |  |  |
Upfront payment conditions |  | The Company incurred an aggregate of $52.8 million in upfront consideration and transaction costs, of which, $44.3 million was paid through the issuance of approximately 1.2 million shares of the Company’s common stock. |  |  |  |  |  |  |  |  |  |  |
Cersci Therapeutics | Research And Development Expense Member |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Assets acquisition and upfront payment |  |  |  |  |  |  | $ 45,700 |  |  |  |  |  |
Stoke Therapeutics, Inc. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Mile stone payments payable | $ 907,500 |  |  |  |  |  |  |  |  |  |  |  |
License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  | $ 10,000 |  |  |  |  |  |  |  |  |  |
Upfront license fee |  |  |  | $ 10,000 |  |  |  |  |  |  |  |  |
License Agreements | Neuren | Research And Development Expense Member | North America |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  | $ 10,000 |  |  | $ 10,000 |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  |  |  |  | $ 3,100,000 |  |  |  | $ 3,100,000 |  |  |  |
Maximum | Cersci Therapeutics |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issuance |  | 1.2 |  |  |  |  |  |  |  |  |  |  |
Maximum | Cersci Therapeutics | Development Commercialization and Sales Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Compensation expense related to mergers to former holders |  | $ 887,000 |  |  |  |  |  |  |  |  |  |  |
Maximum | License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  |  | $ 515,000 | $ 455,000 |  |  |  | $ 515,000 |  |  |  |  |

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