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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 134,563 $ 115,221 $ 250,031 $ 221,775
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,667 $ 2,526 $ 5,617 $ 4,711
License fees and royalties   2,680   5,187
Research and development 75,646 56,935 204,501 113,908
Selling, general and administrative 89,901 96,789 186,580 208,450
Total operating expenses 168,214 158,930 396,698 332,256
Loss from operations (33,651) (43,709) (146,667) (110,481)
Interest income, net 580 133 685 333
Other (loss) income (497) 178 (157) 323
Loss before income taxes (33,568) (43,398) (146,139) (109,825)
Income tax expense 443 473 928 494
Net loss $ (34,011) $ (43,871) $ (147,067) $ (110,319)
Earnings Per Share, Basic $ (0.21) $ (0.27) $ (0.91) $ (0.69)
Earnings Per Share, Diluted $ (0.21) $ (0.27) $ (0.91) $ (0.69)
Weighted Average Number of Shares Outstanding, Basic 161,654 160,421 161,443 160,217
Weighted Average Number of Shares Outstanding, Diluted 161,654 160,421 161,443 160,217