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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities    
Net loss $ (147,067) $ (110,319)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 35,475 35,189
Amortization of premiums and accretion of discounts on investment securities 547 1,176
Amortization of intangible assets 0 739
Loss (gain) on strategic investment 158 (323)
Depreciation 1,031 1,085
Changes in operating assets and liabilities:    
Accounts receivable, net (3,587) (3,120)
Interest and other receivables 42 1,582
Inventory 1,465 (878)
Prepaid expenses 2,940 (512)
Operating lease right-of-use assets 3,172 3,289
Other assets 9
Accounts payable 4,978 572
Accrued liabilities 16,854 (11,331)
Operating lease liabilities (3,972) (2,583)
Long-term liabilities (1,490) (51)
Net cash used in operating activities (89,454) (85,476)
Cash flows from investing activities    
Purchases of investment securities (125,377) (202,526)
Maturities of investment securities 200,925 217,317
Purchases of property and equipment 0 (1,121)
Net cash provided by investing activities 75,548 13,670
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 6,298 12,731
Net cash provided by financing activities 6,298 12,731
Effect of exchange rate changes on cash 6 3
Net increase (decrease) in cash, cash equivalents and restricted cash (7,602) (59,072)
Cash, cash equivalents and restricted cash    
Beginning of period 153,205 331,798
End of period $ 145,603 $ 272,726