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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		9 Months Ended		12 Months Ended
	Jan. 31, 2022	Aug. 31, 2018	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2018	Dec. 31, 2021	Dec. 31, 2020
Other Commitments [Line Items]
Gain (loss) on strategic investment					$ 1,998	$ 706
Research and development			$ 81,336	$ 58,565	285,837	172,473
Restricted cash			5,770	$ 5,770	5,770	$ 5,770		$ 5,770	$ 5,770
Letter of Credit | Corporate Credit Card Program
Other Commitments [Line Items]
Restricted cash			2,000		2,000
Letter of Credit | Fleet Program
Other Commitments [Line Items]
Restricted cash			400		400
Stoke Therapeutics, Inc. [Member]
Other Commitments [Line Items]
Upfront payment	$ 60,000
Mile stone payments payable	$ 907,500
License Agreements | Neuren | North America
Other Commitments [Line Items]
Mile stone payments payable			10,000		10,000
Upfront license fee		$ 10,000
License Agreements | Neuren | Research And Development Expense Member | North America
Other Commitments [Line Items]
Upfront payment							$ 10,000
Maximum
Other Commitments [Line Items]
Mile stone payments payable			$ 1,600,000		$ 1,600,000
Maximum | License Agreements | Neuren | North America
Other Commitments [Line Items]
Mile stone payments payable		$ 455,000

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