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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Revenues        
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 130,714 $ 131,612 $ 380,745 $ 353,387
Operating expenses        
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 2,136 $ 3,688 $ 7,753 $ 8,399
License fees and royalties   2,994   8,181
Research and development 81,336 58,565 285,837 172,473
Selling, general and administrative 78,108 81,666 264,688 290,116
Total operating expenses 161,580 146,913 558,278 479,169
Loss from operations (30,866) (15,301) (177,533) (125,782)
Interest income, net 2,295 129 2,980 462
Other (loss) income 2,156 383 1,999 706
Loss before income taxes (26,415) (14,789) (172,554) (124,614)
Income tax expense 768 (332) 1,696 162
Net loss $ (27,183) $ (14,457) $ (174,250) $ (124,776)
Earnings Per Share, Basic $ (0.17) $ (0.09) $ (1.08) $ (0.78)
Earnings Per Share, Diluted $ (0.17) $ (0.09) $ (1.08) $ (0.78)
Weighted Average Number of Shares Outstanding, Basic 161,852 160,663 161,580 159,651
Weighted Average Number of Shares Outstanding, Diluted 161,852 160,663 161,580 159,651