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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets |  |
NOL carryforwards | $ 225,993 | $ 229,476
R&D credit carryforwards | 83,074 | 74,702
Stock-based compensation | 51,661 | 51,170
Charitable contributions | 42,677 | 41,355
Capitalized R&D | 38,507 | 0
Intangibles | 24,030 | 6,741
Lease liabilities | 14,730 | 15,550
Other | 13,770 | 11,700
Total deferred tax assets | 494,442 | 430,694
Valuation allowance | (481,210) | (416,630)
Deferred tax liabilities |  |
Right-of-use assets | (13,203) | (14,063)
Propery and equipment | (29) | (1)
Total deferred tax liabilities | (13,232) | (14,064)
Total net deferred tax assets | $ 0 | $ 0

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