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v3.22.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |  |
Net loss | $ (215,975) | $ (167,870) | $ (281,584)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 68,201 | 63,615 | 84,422
Amortization of premiums and accretion of discounts on investment securities | (2,736) | 2,404 | 1,470
Amortization of intangible assets | 0 | 1,108 | 1,477
(Gain) loss on strategic investment | (3,542) | (2,329) | 997
Depreciation | 2,026 | 2,236 | 1,455
Loss on disposal of assets | 0 | 0 | 281
Non-cash in-process research and development | 0 | 0 | 44,280
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | 2,171 | (16,119) | (12,466)
Interest and other receivables | 93 | 1,057 | 58
Inventory | 2,415 | (4,210) | (3,320)
Prepaid expenses and other current assets | 2,494 | 1,802 | (7,088)
Operating lease right-of-use assets | 6,566 | 6,287 | 4,280
Other assets | (48) | 10 | 182
Accounts payable | 5,870 | (1,617) | 1,271
Accrued liabilities | 24,306 | (8,455) | 27,569
Operating lease liabilities | (7,916) | (5,433) | (1,769)
Long-term liabilities | 2,040 | 1,854 | 2,319
Net cash used in operating activities | (114,035) | (125,660) | (136,166)
Cash flows from investing activities |  |  |
Purchases of investment securities | (363,174) | (492,797) | (339,908)
Maturities of investment securities | 436,415 | 422,817 | 540,004
Net purchases of property and equipment | 0 | (1,122) | (7,587)
Net cash (used in) provided by investing activities | 73,241 | (71,102) | 192,509
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 8,199 | 18,162 | 80,996
Net cash provided by financing activities | 8,199 | 18,162 | 80,996
Effect of exchange rate changes on cash | 6 | 7 | (8)
Net (decrease) increase in cash, cash equivalents and restricted cash | (32,589) | (178,593) | 137,331
Cash, cash equivalents and restricted cash |  |  |
Beginning of period | 153,205 | 331,798 | 194,467
End of period | 120,616 | 153,205 | 331,798
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 2,190 | 1,038 | 1,113
Supplemental disclosure of noncash information: |  |  |
Property and equipment purchases in accounts payable and accrued liabilities | 0 | 0 | 130
Value of common stock issued in connection with asset acquisition | $ 0 | $ 0 | $ 44,280

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