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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Income Tax Disclosure [Abstract] |  |  |
Amounts computed at statutory federal rate | $ (44,823) | $ (35,179) | $ (59,004)
Stock-based compensation and other permanent differences | 9,050 | 6,696 | 991
Write-off of IP R&D | 2,449 | 1,277 | 9,565
R&D credits | (9,974) | (11,727) | (17,909)
Change in valuation allowance | 11,227 | 36,099 | 5,925
State taxes | (2,232) | (2,617) | (5,038)
Contingencies | 6,993 | 3,879 | 2,665
Foreign rate differential | (1,971) | 2,857 | 4,208
Limitation on executive compensation | 3,918 | 1,808 | 3,705
Deferred rate adjustment | 922 | (2,424) | 2,130
Switzerland tax reform | 0 | (923) | 53,045
Epiration of attributes | 16,142 | 0 | 0
GILTI | 10,804 |  |
Other | (26) | 605 | 328
Income tax expense | $ 2,531 | $ 351 | $ 611

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