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Selected Quarterly Financial Data (Unaudited) | 12 Months Ended
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Dec. 31, 2022
Quarterly Financial Information Disclosure [Abstract] |
Selected Quarterly Financial Data (Unaudited) | 11. Selected Quarterly Financial Data (Unaudited) The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for the years ended December 31, 2022 and 2021 are as follows (in thousands, except per share data):
|  | Fiscal Year 2022 Quarters |  |  |  |
|  | 1st |  |  | 2nd |  |  | 3rd |  |  | 4th |  |  | Total |
Revenues |  | $ | 115,468 |  |  | $ | 134,563 |  |  | $ | 130,714 |  |  | $ | 136,490 |  |  | $ | 517,235 |
Gross profit(1) |  | $ | 112,518 |  |  | $ | 131,896 |  |  | $ | 128,578 |  |  | $ | 134,076 |  |  | $ | 507,068 |
Net loss |  | $ | (113,056 | ) |  | $ | (34,011 | ) |  | $ | (27,183 | ) |  | $ | (41,725 | ) |  | $ | (215,975 | )
Basic and diluted net loss per share(2) |  | $ | (0.70 | ) |  | $ | (0.21 | ) |  | $ | (0.17 | ) |  | $ | (0.26 | ) |  | $ | (1.34 | )
|  | Fiscal Year 2021 Quarters |  |  |  |
|  | 1st |  |  | 2nd |  |  | 3rd |  |  | 4th |  |  | Total |
Revenues |  | $ | 106,554 |  |  | $ | 115,221 |  |  | $ | 131,612 |  |  | $ | 130,758 |  |  | $ | 484,145 |
Gross profit(1) |  | $ | 104,369 |  |  | $ | 112,695 |  |  | $ | 127,924 |  |  | $ | 128,314 |  |  | $ | 473,302 |
Net loss |  | $ | (66,448 | ) |  | $ | (43,871 | ) |  | $ | (14,457 | ) |  | $ | (43,094 | ) |  | $ | (167,870 | )
Basic and diluted net loss per share(2) |  | $ | (0.42 | ) |  | $ | (0.27 | ) |  | $ | (0.09 | ) |  | $ | (0.27 | ) |  | $ | (1.05 | )
(1) Determined by subtracting cost of product sales from product sales, net. (2) Basic and diluted net loss per common share are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.

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- Definition The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -URI https://asc.fasb.org/topic&trid=2126967 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1B -URI https://asc.fasb.org/extlink&oid=126900988&loc=SL124452896-108306 + Details
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