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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenues      
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 517,235 $ 484,145 $ 441,755
Operating expenses      
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 10,166 $ 10,843 $ 10,211
License fees and royalties 0 8,298 10,339
Research and development 361,575 239,415 319,130
Selling, general and administrative 369,090 396,028 388,661
Total operating expenses 740,831 654,584 728,341
Loss from operations (223,596) (170,439) (286,586)
Interest income, net 6,610 591 6,610
Other income (expense) 3,542 2,329 (997)
Loss before income taxes (213,444) (167,519) (280,973)
Income tax expense 2,531 351 611
Net loss $ (215,975) $ (167,870) $ (281,584)
Net loss per common share, basic $ (1.34) [1] $ (1.05) [1] $ (1.79)
Net loss per common share, diluted $ (1.34) [1] $ (1.05) [1] $ (1.79)
Weighted average common shares outstanding, basic 161,683 160,493 157,331
Weighted average common shares outstanding, diluted 161,683 160,493 157,331
[1] Basic and diluted net loss per common share are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.