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Income Taxes - Additional Information (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Tax [Line Items]      
State income tax provision $ 2,500 $ 400 $ 400
Foreign Income Tax Expense (Benefit)     200
Charitable contribution carryforwards 42,677 41,355  
Federal R&D credit carryforwards 74,200    
Increase in valuation allowance of deferred tax assets 64,600    
Unrecognized tax reserves recorded during period 5,100 4,100 $ 2,900
Deferred tax assets 1,200    
Interest and/or penalties accrued 0 $ 0  
R&D Credit Carryforwards Expiring 2023      
Income Tax [Line Items]      
Federal R&D credit carryforwards 300    
Federal      
Income Tax [Line Items]      
Operating loss carryforwards $ 480,200    
Remaining net operating loss carryforward, expiration year 2032    
Federal | Operating Loss Carryforwards Expiring 2029      
Income Tax [Line Items]      
Operating loss carryforwards $ 19,200    
State      
Income Tax [Line Items]      
Operating loss carryforwards $ 486,400    
Remaining net operating loss carryforward, expiration year 2025    
Charitable contribution carryforwards $ 179,800    
Research and development credit carryforwards with no expiration date 19,100    
State | Expiring in 2024      
Income Tax [Line Items]      
Net operating loss carryforwards with no expiration date 3,200    
State | Operating Loss Carryforwards Expiring 2024      
Income Tax [Line Items]      
Operating loss carryforwards 143,400    
Foreign      
Income Tax [Line Items]      
Operating loss carryforwards 1,130,300    
Net operating loss carryforwards with no expiration date 4,400    
Foreign | Operating Loss Carryforwards Expiring 2023      
Income Tax [Line Items]      
Operating loss carryforwards $ 266,500